I got (to date) two comments on how I structure plone instances, which prompts me to share some additional thoughts.
My name is Reinout van Rees and I program in Python, I live in the Netherlands, I cycle recumbent bikes and I have a model railway.
Most of my website content is in my weblog. You can keep up to date by subscribing to the automatic feeds (for instance with Google reader):
http://bitmonk.net/blog/archive/2007/05/22/buildout-instancemanager